Mechanochemistry as a Solvent-Free Manufacturing Platform for Industrial Chemical Processes

Abstract: Mechanochemistry has seen a resurgence of interest as a solvent-free synthetic platform due to the increasing need for environmentally friendly, energy-efficient, and sustainable chemical manufacturing. Mechanochemistry eliminates or significantly reduces the need for bulk solvents by using mechanical force, such as that produced by grinding, milling, or extrusion, to start and maintain chemical transformations in the solid state. The principles of mechanochemical activation, recent technological developments that allow industrial scalability, and representative applications in environmental engineering, materials science, and pharmaceuticals are all critically examined in this review. Green chemistry metrics, techno-economic factors, and the function of continuous mechanochemical processes in contemporary manufacturing are given special attention. Mechanochemistry is positioned as a revolutionary strategy for next-generation industrial chemical processes in the review’s conclusion, which also discusses current issues and future prospects.

Keywords: Mechanochemistry, Solvent-Free Manufacturing, Industrial Chemical Processes